What makes a given restaurant location cursed?

Do you ever worry that a restaurant will be closing before it has even opened? There are locations across the city that feel cursed, destined to be a revolving door of concepts and hopeful restaurateurs.

Fat City is hopeful that the Marrakech Cafe can overcome the hex at 4116 Broadway, where a Cuban restaurant, hot-dog joint, Mexican breakfast restaurant, Bavarian bistro, and fried-fish spot have all failed previously. So what is it that dooms one location to be an ever-changing cast of cuisine?